Protective Effects of Hesperetin Against Lipopolysaccharide-induced Acute Renal Injury in Rat

Objective: In this study, it was aimed to investigate the effects of hesperetin on renal transforming growth factor-beta 1 (TGF-beta 1) expression and apoptosis in rat lipopolysaccharide (LPS)-induced acute renal injury model. Methods: In the study, 18 adult male Wistar albino rats were used. Rats divided into three groups, respectively (n=6); control, LPS and LPS + hesperetin. Sepsis model was created with a singledose of LPS (Escherichia coli, O26: B6 serotype, Sigma-aldrich). LPS + hesperetin group was administered intragastrically with the aid of hesperetin oral gavage at a dose of 100 mg/kg, after LPS-induction. Twenty four hours after LPS administration, the rats were opened from the midline under ketamine-xylazine anesthesia and kidney tissue and cardiac blood were collected. Kidney tissue was examined with hematoxylin-eosin staining. TGF-beta 1 expression was determined by indirect immunohistochemical method. TUNEL method was used to determine renal apoptosis. Blood urea nitrogen (BUN) and creatinine levels in blood serum were determined using spectrophotometric methods. Results: Decreased histopathological changes, TGF-beta 1 expression and apoptosis were determined in the LPS + hesperetin group compared to the LPS group (p<0.05). In addition, a significant decrease in BUN and creatinine levels was observed in the LPS + hesperetin group compared to the LPS group (p<0.05). Conclusion: The data obtained show that in the LPS-induced rat sepsis model, hesperetin suppresses the expression of TGF-beta 1 in kidney tissue and provides a protective effect

The Effect of Stocking Density on Yield, Growth, and Feed Efficiency of Himri Barbel (Barbus luteus) Nursed in Cages

Himri barbel (Barbus luteus Heckel, 1843) fingerlings (mean wt 15.73 g) were stocked at 40, 60, 80, or 100 fish per cage in 1-m3 cages suspended in a reservoir lake to determine total yield, growth rate, and feed efficiency after seven months. Total yields increased as the stocking den- sity increased and were 3.59, 4.80, 6.32, and 7.91 kg per cage, respectively. The highest mean fish weight was obtained in the lowest stocking density. Neither the food conversion ratio nor the mortality rate was affected by stocking density

Properties of gypsum particleboard with added mineral dolomite

Red pine (Pinus brutia) wood particles and dolomite mineral were used in varying proportions to form mineral-added gypsum particleboards. Mechanical, physical, and chemical properties of the boards were tested. The increasing &nbsp;mineral content was found to improve the water absorption properties but the increased amount of&nbsp; gypsum&nbsp; in the mixture negatively affected the thickness swelling and water absorption properties. The usage of dolomite mineral in the board composition increased the internal bond properties and higher than the standard of 0,28 MPa. However, all types of boards had modulus of elastic, modulus of rupture and thermal conductivity results values below the standards.&nbsp; Moreover, the thermal conductivity values decreased in all board types because of the reduction of the mineral dolomite. Thermal gravimetric analysis, Fourier transform infrared spectrometry tests were applied to examine the thermal and flame retardancy properties of inorganic materials, wood-gypsum composites, which are used at different rates for synergistic effect. The gypsum and dolomite amount affected the thermal variation, whereas the increment in the weight of the wood particles also increased the thermal degradation. It was determined that stresses at 850-980 cm-1 reveal Ca-O and Mg-O, reveal at 881cm-1 C-OH, weak vibration at 1619 cm-1 and a strong bond structure in the 1445-950-882 cm-1 bands. These bands express the characteristic presence of the CaO and MgO belonging to dolomite. The study demonstrated the feasibility of producing mineral-based gypsum board products using wood chips

ÇOK AŞAMALI PROSESLERDE ÖRNEK HACMİNİN BELİRLENMESİÜZERİNE BİR MODEL VE GENETİK ALGORİTMALAR YARDIMIYLA ÇÖZÜM ÖNERİSİ

Bu çalışmada, çok aşamalıkabul örneklemesi problemleri için Genetik Algoritma GA yaklaşımıincelenmiştir. Langner 2001 tarafından geliştirilen model kullanılarak, çok aşamalımuayene probleminin çözümüne ilişkin Visual Basic 6.0 programlama dilinde bir program hazırlanmışve GA ile çözülen bu modelden elde edilen sonuçlar ANSI/ASQC Z1.4 örnekleme planıile karşılaştırılmıştır. Her iki örnekleme planıiçin elde edilen örnek hacmi n ve kabul edilebilir kusur sayısı c değerleri için çalışma karakteristiği OC-Operating Characteristics ve Kabul Olasılığı Pa eğrileri WinQSB yardımıyla çizilerek sonuçlar karşılaştırılmıştır

Capital flows, EU integration and the global financial crisis:an empirical analysis

We investigate the impact of European Union (EU) integration on capital flows to prospective new EU member states. Using annual data between 1992 and 2020, our results suggest that although EU integration increased net capital flows before the Global Financial Crisis (GFC), it was not able to shield countries from the general decline in capital flows that occurred after the GFC. Furthermore, the results show that the impact of EU integration mainly runs through improved institutional quality. We also find considerable heterogeneity in the drivers of different types of capital flows (FDI, portfolio investments, and other capital flows) that we consider

A fuzzy multiple attribute utility model for intelligent building assessment

Multi-Attribute Utility Theory (MAUT) is an evaluation scheme which is very popular by decision makers for evaluating their judgments. According to MAUT, the overall evaluation U(x) of an object x is defined as a weighted addition of its evaluation with respect to its relevant value dimensions. The recent years have witnessed a huge concentration and interest in intelligent buildings’ performance that is increasingly evidenced in building design and construction. Intelligent buildings (IBs) are also under assessment according to their IB related characteristics and actual circumstances. For this aim, in this paper a fuzzy multiple attribute utility model for intelligent building assessment is proposed and three alternative intelligent buildings for a business center in Istanbul are evaluated

A comparison of fuzzy multicriteria decision making methods for intelligent building assessment

The methodology, Multicriteria Decision Making (MCDM), refers to finding the best alternative from all of the feasible alternatives in the presence of multiple, usually conflicting, decision criteria. Nowadays, intelligent buildings’ performance that is increasingly evidenced in building design and construction has been analyzed by using MCDM techniques. Intelligent buildings (IBs) are also under assessment according to their IB related characteristics and actual circumstances as a MCDM problem. In this paper, two most known MCDM methodologies, Analytic Hierarchy Process (AHP) and TOPSIS (Technique for Order Preference by Similarity to Ideal Solution), are used for intelligent building assessment under fuzzy environment for dealing with the evaluations’ uncertainty and imprecision in which the expert's comparisons that are represented as fuzzy numbers. For this aim, three intelligent building alternatives for a business centre in Istanbul are evaluated by using these two fuzzy MCDM methods and the obtained ranking results are compared

PERSONEL SEÇİM SÜRECİNDE UZMAN SİSTEM YAKLAŞIMI VE KONYA BÜYÜKŞEHİR BELEDİYESİNDE BİR UYGULAMA

Bu çalışmada, yapay zekanın bir alt disiplini olan uzman sistemler US incelenmişve personel seçimine yönelik “Expert-Personel” adında bir uzman sistem geliştirilmiştir. Sistem, Konya Büyükşehir Belediyesinde, Belediye Başkan Yardımcısı, Çevre Koruma Daire Başkanıve Çevre Şube Müdürü seçimine yönelik olarak uygulanmıştır. Bu birimler için işanalizi ve görev tanımlarıyapıldıktan sonra uygun bir işbaşvuru formu oluşturulmuştur. Ayrıca adayların kişilik özelliklerini belirlemeye yönelik kişilik belirleme sorularıoluşturulmuşve en uygun adaylar “Expert-Personel” uzman sistemi yardımıile belirlenmiştir

A Study on Composite Panels Prepared from Mixture of Mineral Adducts with Calabrian Pine Tree (Pinus brutia) Residues

The heat transfer coefficient values of 0.250 W/mK and l: 0.261 W/mK were found for Type 1 boards (bark based experimental boards of XBI and YBV)and l: 0.321 W/mK and l: 0.311 W/mK were found for Type 2 boards (cone based experimental boards of XCV and YCII), respectively. But all these are lower than standard value of 0.065 W/mK. However, visual evaluation show that all samples have low flame spreading properties which did not reach the threshold limit of 150 mm under a single flame combustion test. All Type 1 boards show lower mass loss (w, %) than control sample (B0: 11.97%), regardless of mineral additive type and proportions. The lowest mass loss of 6.36% was obtained with sample of YBIV. It is noticeable that olivine-cone (YC) and olivine-bark (YB) based panels usually show lower mass loss than dolomite-cone and dolomite-bark based panels at similar experimental conditions. The surface burning tests clearly indicate that the both mineral additions have lowering effects on burning feature of boards. This is probably olivine and dolomite could be absorbing heat and release water. Hence the burning area might become colder during evaporation of water with increasing charring and improve insulation of materials. The heat insulation levels of boards have found to be closely related with mineral content. But olivine seems to more effective for improving insulation properties for Type 1 boards. It is also found that both type panels (Type 1 and 2) which prepared from various proportions of dolomite and olivine as additives (10-50%) were show higher resistance against thermal degradation than control panels which prepared only (100%) from lignocellulosic material (cone and bark)